To strengthen our excellent research team, which
is focused on the development and research of innovative approaches for the
treatment of childhood cancer, we are looking for three
The focus of the Boztug group is on the identification of rare monogenic disorders of the immune system and hematopoiesis, as well as inherited predisposition to cancer, to explain pathophysiological manifestations in humans (e.g., Salzer E et al., Science Immunology 2020; Kalinichenko A et al., Blood 2021; Wang L et al., Nat Genet 2021). In the context of this work, the Boztug group applies a combination of state-of-the-art genetic and genomic technologies including next generation sequencing (NGS) and a wide range of cellular and molecular techniques to elucidate novel pathways important for immune system homeostasis. The project, funded by an ERC Consolidator Grant, will investigate the interplay of immunodeficiency, alterations of cellular metabolism and cancer predisposition.
The Seruggia group is interested in gene regulation in the context of pediatric cancer, and focuses on the study of non-coding regulatory sequences (enhancers) as well as protein complexes involved in the control of gene expression. The Seruggia group uses a variety of CRISPR screening modalities (e.g. Seruggia et al., Mol Cell 2019; Sher, Hossain, Seruggia, Nat Genet 2019), chromatin profiling (ChIP-seq, CUT and RUN, ATAC-seq), proteomics, mouse models and computational approaches to identify and characterize cancer vulnerabilities. The project, funded by an ERC Starting Grant, will investigate how mutations at enhancers drive leukemia development and will elucidate the effect of sequence variation at transcription factor binding sites.
The Taschner-Mandl group tackles unresolved questions of neuroblastoma pathogenesis and develops new diagnostic and therapeutic approaches to facilitate precision medicine for children with malignant tumors (e.g. Weiss T et al., Nat Comm 2021, Gerber T et al., J MolDiagn, 2020, Kromp F et al., Sci Data, 2020). The Taschner-Mandl group studies determinants of inter- and intra-tumor heterogeneity and aggressiveness in neuroblastoma by combining molecular biology and computer-based research. This project, will use automated microscopy and apply and compare machine/deep-learning-based approaches for image analysis, cell and tissue classification with the goal to develop new diagnostics.
Each group offers the unique opportunity to join them as a Master student (m/f/d) in fascinating projects.
As a Master student, you will
· Join an exciting, multi-disciplinary environment with lots of support for your personal and professional development from your supervisor, team, and peers
· Learn to take on ambitious research in close collaboration with experimental and clinical researchers
· Contribute from the start including planning of experiments and data acquisition
· Provide thorough and creative thinking that makes the projects a success
· Monitor the literature and community resources to keep abreast latest developments and to identify information, data, and methods to integrate in your own work
· Bachelor's degree in a relevant subject, depending on the project you are applying for (e.g. biology, biochemistry, biomedical engineering, medical informatics, computer vision)
· Excellent technical skills, depending on the project you are applying for, e.g. cell culture, nucleic acid isolation, qPCR, programming skills (Phyton, Shellscript), machine/deep learning
· Experience (e.g. internships) in a relevant area is a plus
· Excellent verbal and written communication skills in English (German not required)
· Self-motivated, enthusiastic and eager to learn
· Good team player, commitment, and creativity
· Scientific mindset, problem solving attitude
· Exciting projects in a meaningful, inspiring, and international setting
· An outstanding working atmosphere in a strong team with excellent opportunities
· Access to state-of-the-art infrastructure
· Flexible working hours, excellent public transport connections and other great benefits
· Great location in the center of Vienna, a capital of biomedical research in Europe with excellent quality of life
· A monthly allowance of € 475,86
Who we are
The St. Anna Children's Cancer Research Institute (CCRI), located in the center of Vienna, the world's most livable city and one of Europe's most important places for biomedical research and life sciences, is an international and multidisciplinary competence center striving to improve treatment of children and adolescents with cancer by connecting translational and clinical research with open-minded exploration of basic disease mechanisms. Through close cooperation between clinic and research, the CCRI provides an ideal environment for cutting-edge research and its translation into clinical practice. To achieve our ultimate goal of advancing the well-being of patients, the CCRI constantly pushes scientific boundaries and strongly promotes close collaboration and exchange with external institutions like the Medical University of Vienna, CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, the Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA) and the Institute of Molecular Pathology (IMP).
The CCRI is an equal opportunity employer. We value diversity and are committed to providing a work environment of mutual respect to everyone regardless of ethnicity, religion, national origin, age, gender identity or expression, disability, or any other characteristic protected by applicable laws, regulations and ordinances.
Please send your application via email to firstname.lastname@example.org. Applications should at least contain your Curriculum Vitae, a cover letter and the contact details of two references. Please indicate in your cover letter, which of the mentioned groups you would like to join.